What causes a lupus flare up and their treatments?

Lupus is an autoimmunity disease that causes your body’s immune systems to attack its own tissues and may affect many different organs, including the joint, muscle, blood vessels, lung, liver, kidney, brain, and nervous systems and what causes a lupus flare up include genetics and environmental factor such as sunlight, infection e.t.c.

Lupus usually presents itself first with a facial rashes that resemble the wings of a butterfly unfurling across both cheeks. Other symptoms include joint pain, fatigue, fever, night sweats, weight loss, mouth sores, swollen glands, and nausea.

Among of what causes a lupus flare up in some people are born genetically predisposed to develop lupus, which may be caused by an infection, certain medications, or even sun exposure. There’s no way to prevent lupis, but there are ways to treat its various symptoms.

Lupus varies from person to person. Some people experience flare up; others don’t. Most people with lupus have milder disease than those who suffer from systemic lupus erythematosus (SLE).

The main features of lupus are its most common symptoms, including fever, joint pain, fatigue, skin rashes, muscle weakness, etc.

• Fatigue
• Fever
• Joint pain, stiffness and swelling
• A butterfly-shaped skin eruption on the face that extends across the cheekbones and bridges the nose is called an urticarial reaction. Rash anywhere else on the body is known as a maculopapular exant
• Skin lesions that may be caused by an allergic reaction to sunlight or by skin cancer
• Shortness of breath
• Chest pain
• Dry eyes
• Headaches, confusion and memory loss

You should always go to the doctor when something unusual happens.

If you develop any unusual symptoms (such as an unexplained red patchy skin eruption), see your healthcare provider immediately. You may need medical attention for the symptoms

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What causes a lupus flare up?

What causes a lupus flare up is a condition that affects multiple organs. It may be caused by both genetic predisposition and environmental influences.

Lupus develops when certain individuals inherit a genetic predisposition towards developing lupus. Most often, the reason why someone develops lupus is not known; some potential causes include exposure to environmental factors (such as infection).

• Sunlight exposure may cause lupus skin lesions in some individuals.
• Lupoid arthritis is often preceded by infections which may trigger the disease.
• Lupus can be caused by certain blood-pressuring drugs, seizure medicines and antibiotic prescriptions. Those who suffer from drug-caused lupus recover once the drug is removed. Occasionally, lupus persists even after the medicine is discontinued.

Lupus is not caused by one thing; doctors don’t know exactly why it happens. They think genes, hormone levels, and your environment may play a role.

Lupoid arthritis, which affects people who have lupoid arthritis, is caused by an overactive immune system.

You might be genetically predisposed to get lupus, but you could also be triggered into developing an autoimmune disease by exposure to certain environmental factors.

In what causes a lupus flare up even though both of these factors could be true at the same time, that doesn’t necessarily make Lupus inevitable. It’s hard for doctors to know what exactly causes lupus, so it can be tough to predict who might develop it.

A few studies have found that there are factors that increase your risk for heart disease, such as your genes, sex, race, and previous illness.

Genetics and Lupus

Your DNA contains the instructions for building the proteins inside your cells. Sometimes these instructions cause diseases.

Scientists from an international team have found a new mutation in a gene that could lead to lupus.The discovery was made by looking at the DNA of patients suffering from systemic lupus erythematosus (SLE).

Usually, an infection triggers our bodies’ natural defense mechanism – the immune response – which protects us from disease. But sometimes, when we’re infected by a virus, a mutation occurs in one of the genes involved in the immune response, causing the immune response to attack the

The scientists found the TLR7 gene mutated in a girl from Spain who had been diagnosed with severe lupoid arthritis when she was seven years old.

After doing some experiments, scientists found that the TLR7 protein plays an important role in causing autoimmune diseases, which may offer new hope for treating them. The findings provide strong evidence that the mutated TLRs cause autoimmune diseases in humans.

Researchers hope their discoveries ultimately help develop new drugs for people with lupus that are more effective and cause less harm.

If one of your parents, siblings, or friends has lupus, then you might be slightly more likely to develop it yourself.

Some racial and ethnic populations may be at greater risk for developing lupus due to genetic factors. If you belong to one of these populations, you may be at increased risk for developing the disease.

• African American
• Asian
• Hispanic/Latino
• Native American
• Native Hawaiian
• Pacific Islander

Women and Lupus

According to doctors, hormones may be responsible for why most lupus patients are female. Both men and woman produce estrogen, but most people think that females produce more than males and that could explain why so many people have lupus.

There’re several things we could look at here. First, research has shown that women have stronger immune systems than men, so hormones may play a role in triggering lupus or making it worse. Second, there are some studies showing that estrogens might be involved in triggering lupus

Lupus symptoms may be triggered by pregnancy hormones, but this doesn’t mean that pregnancy hormones cause lupus.

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Environmental Triggers

Among of what causes a lupus flare up the researchers believe that simply having lupus doesn’t mean you’re going to develop the condition. It may take an additional trigger for the disease to occur.

These triggers may include:

Sunlight: Ultraviolets, or UV, light from the Sun damages your cells. That’s why you get sun burn. But in some peole, the Immune system attack the sun burned, or damaged, cells.

Ultraviolet radiation may trigger lupoid arthritis, but it could also be worsening its symptoms. People who suffer from lupoid arthritis often feel pain and fatigue when they’re under the sun.

When an individual gets sick, his/her body’s natural defenses fight against the infection. However, in patients having Lupus, the body’s defense mechanism fails to stop further spread of the disease. Therefore, doctors do not understand why.

Lupus-linked viruses include:

• Cytomegalovirus
• Epstein-Barr virus, which causes mononucleosis
• Varicella-zoster virus, which causes chickenpox and shingles

Medications. Certain medications can trigger an autoimmune reaction that causes what’s known as drug-induced lupis. Lupis usually goes away within weeks if not months. More than fifty different medications have been associated with lupis, ranging from heart medications such as beta blockers to treatments for diabetes, hypertension, and viral infections.

Lupus may be caused by drug reactions to medications such as

• Hydralazine for high blood pressure
• Penicillamine for rheumatoid arthritis
• Procainamide for heart rhythm problems
• Quinidine may be prescribed for certain health conditions — including arr

Once you’ve stopped using drugs that cause your symptoms, you generally experience improvement.

• Lupus isn’t caused by any one drug. However, certain medicine can worsen symptoms if you already have lupus. These drugs are called “lupus flares.” They’re not causes of lupus, but they may trigger an existing
• Some Antibiotics, such as Pen
• PABA, which may be found in some sunscreens, is sometimes prescribed for people who suffer from autoimmune diseases like scleroderma and dermatomyositis.
• Cimetidine (Tagamat) is an antacid used
• Golimumab, an immuno­suppressant used for treating certain autoimmune diseases, has been linked to heart failure and infections
• Hydrochlorothiazide, which helps your body excrete excess fluid, is known by its brand name Diuril.
• Omeprazole, a heartburn medication
• Terbinafine, an anti-fungal medication used to treat athlete’s foot, Jock itch, and fungal infections on your

Toxins, Research shows that toxins are linked to lupus; however, no one knows for sure if they cause it directly.

Mercury and silica aren’t going away anytime soon. So if you work in an industry that exposes you to mercury and silica, ask your physician for advice. Also, it’s never too late to quit smoking.

Lupis are triggered by stressful events. Although there isn’t proof that stress causes lupis, it has been shown to trigger flares in people who already have lupis.

Stressful events that may make your symptoms worse could be:

• A death in the family
• Divorce
• Extreme fatigue
• Injury
• Pregnancy/childbirth
• Surgery

Mercury and silica exposure may be harmful for some people. Talk to your doctor if you think you might be affected by these things. Also, it’s always a good practice to stop smoking.

A death in the family.

• Divorce
• Extreme fatigue
• Injury
• Pregnancy/childbirth
• Surgery

When you feel stressed out about everyday problems, try taking a walk or getting outside and enjoying nature. You might also find help through counseling or meditation or prayer.

If you’re experiencing a difficult time, or need inspiration to cope better with tough situations, consider seeking out counseling. A few sessions may help you deal better.

Risk factors

Some factors that may increase your chances of developing lupus are:

• Gender. Lupus is more prominent among women than men.
• Lupus affects people of all age groups but is usually first detected between the age of 15 and 45.
• Lupus affects people from different ethnic backgrounds. It’s most commonly found among African Americans,

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Complications

Among of what causes a lupus flare up  and trigger Lupus inflammation can cause many different symptoms in your body, including:

• Kidneys: Lupus can cause serious kineNdyDeathMAnageR, and kineNeFulaReaDmEanageR is one of the leading causes o f your brain and spinal cord are connected to each other through nerves called axons. When these nerves become inflamed (swollen) they can cause pain and discomfort in different
• lupus may cause anemia and also increase the likelihood of bleeds or clots.
• Lupes makes it harder for your lungs to breathe. Bleedings in the lungs and pneumonia are also possible.
• Lupus can lead to inflammation of your arteries, which increases your chances of having a stroke or a brain hemorrhage, both of which are life threatening conditions.

Other types of complications

Lupo­sclerosis can increase your risks for:

• Lupus patients are at greater risk for infections because both their lupus and its treatment may weaken their immune systems.
• Lupas are associated with an increased risk of lung, breast, and ovarian cancers. According to the National Institute for Occupational
• Loss of calcium from bones. Calcium is one of the most important minerals for maintaining strong bones. As we age, our bodies begin to lose some of their ability to absorb calcium from foods. Because of this loss, osteoporosis often results.
• Lupus can cause serious problems during pregnancy. One of the main risks is high blood pressure (hypertension). Another problem is premature delivery. Both conditions increase the risk of miscarriage. So, if possible, wait to get pregnant until you’ve had controlled symptoms for 6 months.

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Diagnosis

To find solution to lupus flare up you must know what causes a lupus flare up because diagnosing lupus is difficult due to its highly variable nature,signs and symptom may differ greatly from one person to another.

A single test cannot diagnose lupoid arthritis; rather, the entire body must be examined for any abnormalities.

Laboratory tests

Blood and Urea Tests include the following

• Complete-body scan. This imaging technique uses special x-rays to produce detailed images of your internal organs.It’s also called computerized tomography (CT) scanning. During the procedure, the CT scanner rotates around you, taking hundreds of pictures of the inside andoutside of your body. These images can detect abnormalities such as tumors, gallstones, cysts, and bone fractures.
• Erythrocytessedimentate (to settle) within an hour in a tube containing anticoagulant. This test determines the speed at which red cells settle to the base of a tube. An elevated sedimented cell count indicates a systemic illness, such assystemic lupus erythematosus (SLE). Sedimented cell counts are not specific for any single disorder. They can be increased due to many conditions, including infections, chronic diseases, cancer, and autoimmune disorders.
• Kidney/liver function can be assessed by blood testing. There are several factors that can impact kidney/liver health, including lupus.
• A urinalysis is a test of a sample of your pee that may reveal an increase in protein levels or red blood cell count. These increases could be caused by lupus affecting your kidney function.
• A&P test. A positive test for these antibodies — made by your immune cells — indicates an activated immune response. Most patients who test positive for ANA don’t actually have lupus. However, if you test positive for ANAs, your physician might suggest more specific tests.

Imaging tests

If your doctor believes that lupus is causing your lungs or your cardiovascular system to malfunction, they might recommend:

• X-Ray. An image of your lungs may show signs of fluid orinflammations in them.
• An electrocardiogram (ECG) measures electrical activity generated by your heartbeat, which helps doctors detect any abnormalities.

Biopsy

Lupus can cause kidney damage in many different ways, so treatments may differ from case to case. Sometimes it’s necessary to test out a small piece of kidney tissue before determining the best course of action. A small biopsy can be obtained with a syringe or by making an incision.

A skin biopsy may be used for diagnosing lupus.

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What Are Treatment of Lupus Flare up?

A treatment plan for lupus should be determined by discussing the pros and cons of each option with your doctor.

Your doctor may be able to help you manage your lupus by changing your medication or dosage. Lupus drugs include:

• Nonsteroidal anti-inflammatory drug (NSAID). Over-the-coun ter medication, such as naproxen sodium, Aleve, Advil, Ibuprofen, Celebrex, and Motrin IB, may be taken to relieve pain, inflammation and swelling caused by Lupus. Stronger NSAIDS are available by prescription. Common side effects of NSAIDs may be stomach bleeding, kidney damage, and an increased chance of heart attack.
• Anti-malarial drugs, including chloroquine and hydroxychloroquine, may impair vision in rare cases. Side effects of anti-malarials can include stomach upset and, very rarely damaged eyesight. Regular exams of your eyes are advised when you take these medications.
• Corticosteroid medication can be given in many forms including oral tablets, injections, cream, ointment or suppositories. Oral tablets may cause dizziness, drowsiness and insomnia whereas injection causes local reactions and potential for infections. Creams may cause rashes. Ointments may cause skin irritation. Suppositories may cause rectal discomfort.
• Immuno suppressive drugs. Drugs that lower the body’s immune response can be used to treat severe cases of lupocephaly. Commonly used examples of such drugs include azathioprin (imuran), mycophenolate mofetil (cellcept), methotrexat (trexal, xatmep), cyclosporin (sandimmune, neoral, gengraf) and lefluonamide (arava). Such drugs may lead to a higher incidence of infections, liver damage, reduced fertility
• A different kind of medicine, Benlysta administered intravenously, also reduces Lupus symptoms in some people. Side effects may be nausea, diarrhea and infection. Rarely, an increase in Lupus activity may occur.
• Rituximabbothat works for some patients, but causes serious side effects including an allergic response to the intravenous injection and bacterial infections.
• Voclosporin has been proven to be an effective treatment for luposmerosis.

There are several potential new treatments for lupis.

How long does a lupus flare up last?

Lupus flares can occur unpredictably. They typically begin with an acute exacerbation (a sudden worsening) of symptoms. These flares may then lead to more frequent episodes of illness. However, these episodes are often not predictable and may come at any time during the course of the disease.

Lupus usually occurs at any time, but may last for several days or even months. Its severity ranges from mild to serious.

When someone has an attack of Lupus, they may experience periods of remission where no symptoms occur. However, researchers do not know why this happens or why these attacks tend to be unpredictable.

How to cure for lupus at home

Diagnosis and treatment

If you’re diagnosed with lupus, take simple steps to look after your body. These may include:

• Make sure you see your doctors regularly. Making regular appointments rather than just seeing them when things get worse may improve their ability to detect flare ups before they occur. It may also be beneficial for dealing with routine health issues, including diet/exercise and emotional states that can affect lupus.
• Wear protective clothing when going out into the sunlight — hats, long sleeves and long pants — use SPF 50+ sun block lotion.
• If you’re not exercising regularly, then get started now! Exercise can improve your health and make you feel better all around.
• Don’t smoke because smoking is bad for your health. It may increase your risk of developing cardiovascular diseases and could be worse for people who already have lupic nephritis.
• Eat a healthy diet. A good diet consists mainly of fresh fruit, vegetables,and whole grains. If you have any nutritional issues, such as high blood pressure, kidneys damage, or digestive issues, you may need to change your diet.
• If you’re taking medications for lupus, ask your physician whether you need additional vitamins D and/or Calcifediol (CalD). Studies show that patients who take these nutrients may be less likely to develop osteoporosis and possibly even experience fewer flare ups or remissions.

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Alternative medicine

Lupus isn’t treatable by alternative or complementary medicines. However, there aren’t any alternative treatments that have been proven effective for treating lupus. Some of these may be helpful for relieving some of the side effects associated with the disease.

Talk to your doctor first if you’re thinking about trying any new treatment for your lupus. Together you can decide whether it’s safe for you, and if so, which one(s) might be best suited to treat your condition effectively.

There are complementary and alternative treatments for lu­pus including:

• Dehy­droepio­pia­dro­nea­ste­rone­sulfo­phat­es (DHEAS)
• Fish Oil. Fish oil contains Omega 3 fatty acids. These may help people with Lupus. However preliminary evidence suggests they could also cause side effects such as nausea and belching. More research needs to be done.
• Acupuncture helps relieve muscle pain caused by lupoid arthritis.

Coping and support

Lupoid arthritis occurs when the body’s immune system attacks joints. Many people experience pain, stiffness, swelling, redness, warmth, loss of motion and/or tenderness. It may be triggered by

• Lupus affects people differently and often hits them without warning. Learn everything you can about lupis and write down any new information that comes to mind so you can talk to your physician about it. If you’re not sure where to get reliable information, ask your healthcare professional or check out Web sites such as www.lupus.org. You may also find answers to specific lupus facts on these Web pages.
• Gather support from your friend and family. Explain lupus to them and tell them how they can help you if you flare up during an episode. Lupus can be difficult for your loved one’s because they often can’t see it, and you might not look sick.
• If you want to be open about your feelings, let your family on what you’re going through.
• Take care of yourself. Spend quality alone moments doing things you enjoy. Make a list of what brings you joy, then do those things. Set aside specific times each day to relax, just you and the world around you. You’ll find peace and renewal through self-care.

What You Can Do

However, what causes a lupus flare up are certain factors link to Lupus, but we cannot say for sure that they cause Lupus.

It doesn’t matter if your sibling or friend has lupus or if you’ve had shingling; no one knows for sure whether they will develop lupus. If you’re concerned, ask your doctor for advice.

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